Dev124750 4329..4339
نویسندگان
چکیده
Tbx5 plays a pivotal role in vertebrate forelimb initiation, and loss-offunction experiments result in deformed or absent forelimbs in all taxa studied to date. Combining single-cell fate mapping and threedimensional cell tracking in the zebrafish, we describe a Tbx5adependent cell convergence pattern that is both asymmetric and topological within the fin-field lateral plate mesoderm during early fin bud initiation. We further demonstrate that a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility. Partial reduction in Tbx5a or Fgf24 levels disrupts the normal fin-field cell motility gradient and results in anteriorly biased perturbations of fin-field cell convergence and truncations in the pectoral fin skeleton, resembling aspects of the forelimb skeletal defects that define individuals with Holt–Oram syndrome. This study provides a quantitative reference model for fin-field cell motility during vertebrate fin bud initiation and suggests that a pre-pattern of anteroposterior fate specification is already present in the fin-field before or during migration because perturbations to these early cell movements result in the alteration
منابع مشابه
ROSAT observations of the IC 4329 A galaxy group ?
We report here the results of high-resolution and spectral imaging X-ray observations, with both the ROSAT HRI and PSPC, of the field surrounding the nearby (D = 64Mpc) type 1 Seyfert galaxy IC 4329A and its giant lenticular companion IC 4329. Many point sources are detected, the brightest being associated with IC 4329A itself, having an extremely bright X-ray luminosity of 6 × 1043 erg s−1, an...
متن کاملGRANT NUMBER DAMD 17 - 94 - J - 4339 TITLE : A Genetic Approach to Identifying Signal Transduction
متن کامل
The role of awareness of repetition during the development of automaticity in a dot-counting task
This study examined whether being aware of the repetition of stimuli in a simple numerosity task could aid the development of automaticity. The numerosity task used in this study was a simple counting task. Thirty-four participants were divided into two groups. One group was instructed that the stimuli would repeat many times throughout the experiment. The results showed no significant differen...
متن کاملRelative evolutionary rate inference in HyPhy with LEISR
We introduce LEISR (Likehood Estimation of Individual Site Rates, pronounced "laser"), a tool to infer relative evolutionary rates from protein and nucleotide data, implemented in HyPhy. LEISR is based on the popular Rate4Site (Pupko et al., 2002) approach for inferring relative site-wise evolutionary rates, primarily from protein data. We extend the original method for more general use in seve...
متن کامل